Seminal plasma HSPA2 mRNA content is associated with semen quality.

ABSTRACT:

Purpose

Cell-free mRNAs (cfmRNAs) were quantitatively measured in human seminal plasma and its relationship with semen quality was investigated.

Methods

Herein, a prospectively, controlled investigation was performed to study seminal plasma HSPA2 and uPA cfmRNA alterations between 21 asthenozoospermic patients and 16 normozoospermic individuals. Standard semen analysis was performed and seminal plasma cfmRNAs content was measured by real-time quantitative PCR. In addition, the regression analysis between seminal plasma cfmRNAs expression and semen parameters was performed.

Results

Seminal plasma HSPA2, but not uPA cfmRNA indicated significant difference between normozoospermia and asthenozoospermia men (P = 0.02444 and 0.07811, respectively). Negative correlation betw

SUBMITTER: Tian Y 

PROVIDER: S-EPMC4974226 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature