Sorafenib in breast cancer treatment: A systematic review and overview of clinical trials.

ABSTRACT:

Aim

To evaluate the current role of sorafenib, an oral multikinase inhibitor in the treatment of breast cancer.

Methods

An extensive search of the literature until March 2016 was carried out in Medline and clinicaltrials.gov, by using the search terms "sorafenib" and "breast cancer". Papers found were checked for further relevant publications. Overall, 21 relevant studies were found, 18 in advanced breast cancer (16 in stage IV and two in stages III-IV) and three in early breast cancer.

Results

Among studies in advanced breast cancer, there were two trials with sorafenib as monotherapy, four trials of sorafenib in combination with taxanes, two in combination with capecitabine, one with gemcitabine and/or capecitabine, one with vinorelbine, one with bevacizumab, one wi

SUBMITTER: Zafrakas M 

PROVIDER: S-EPMC4974240 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature