Urinary Proteomics Yield Pathological Insights for Ureteropelvic Junction Obstruction.

ABSTRACT: Prenatal hydronephrosis is a common condition that may spontaneously resolve after birth. However, this condition can result in renal damage and requires surgical correction in a number of cases. Preventing renal damage is paramount, but existing diagnostic technology is invasive, exposes infants to radiation, is costly, and is often indeterminate. A better understanding of the pathophysiology of renal obstruction as reflected in the urinary proteome may provide new insights into the disease that could potentially alter the clinical management of hydronephrosis. We performed a quantitative proteomics study of urine that was surgically obtained from eight clinically significant, unilaterally obstructed infants versus eight healthy controls, with the goal of identifying quantitatively varyin

SUBMITTER: Froehlich JW 

PROVIDER: S-EPMC4974339 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature