Competition and fixation of cohorts of adaptive mutations under Fisher geometrical model.

ABSTRACT: One of the simplest models of adaptation to a new environment is Fisher's Geometric Model (FGM), in which populations move on a multidimensional landscape defined by the traits under selection. The predictions of this model have been found to be consistent with current observations of patterns of fitness increase in experimentally evolved populations. Recent studies investigated the dynamics of allele frequency change along adaptation of microbes to simple laboratory conditions and unveiled a dramatic pattern of competition between cohorts of mutations, i.e., multiple mutations simultaneously segregating and ultimately reaching fixation. Here, using simulations, we study the dynamics of phenotypic and genetic change as asexual populations under clonal interference climb a Fisherian landsca

SUBMITTER: Moura de Sousa JA 

PROVIDER: S-EPMC4975028 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature