Insulin glargine use and breast cancer risk: Associations with cumulative exposure.

ABSTRACT:

Background

This study was aimed to assess the risk of breast cancer associated with exposure to insulin glargine in women with type 2 diabetes and evaluate whether the pattern of risk concurs with the hypothesized trend of an increase in risk with longer duration of use, taking into account previous cumulative exposure to other types of insulin.

Methods

We performed a restrospective cohort study (2002-2013) in the Clinical Practice Research Datalink among adult female patients with a first ever insulin prescription (n = 12 468). Time-dependent exposure measures were used to assess associations with duration of use of: (1) other insulin types before glargine was first prescribed (i.e. among switchers); and (2) of glargine during follow-up. Analyses were performed separately f

SUBMITTER: Peeters PJ 

PROVIDER: S-EPMC4975082 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature