Hydrogen Peroxide Induced Cell Death: The Major Defences Relative Roles and Consequences in E. coli.

ABSTRACT: We recently developed a mathematical model for predicting reactive oxygen species (ROS) concentration and macromolecules oxidation in vivo. We constructed such a model using Escherichia coli as a model organism and a set of ordinary differential equations. In order to evaluate the major defences relative roles against hydrogen peroxide (H2 O2), we investigated the relative contributions of the various reactions to the dynamic system and searched for approximate analytical solutions for the explicit expression of changes in H2 O2 internal or external concentrations. Although the key actors in cell defence are enzymes and membrane, a detailed analysis shows that their involvement depends on the H2 O2 concentration level. Actually, the impact of the membrane upon the H2 O2 stress felt by the

SUBMITTER: Uhl L 

PROVIDER: S-EPMC4975445 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature