Characterization of Cells Isolated from Genetic and Trauma-Induced Heterotopic Ossification.

ABSTRACT: Heterotopic ossification (HO) is the pathologic formation of bone separate from the normal skeleton. Although several models exist for studying HO, an understanding of the common in vitro properties of cells isolated from these models is lacking. We studied three separate animal models of HO including two models of trauma-induced HO and one model of genetic HO, and human HO specimens, to characterize the properties of cells derived from tissue containing pre-and mature ectopic bone in relation to analogous mesenchymal cell populations or osteoblasts obtained from normal muscle tissue. We found that when cultured in vitro, cells isolated from the trauma sites in two distinct models exhibited increased osteogenic differentiation when compared to cells isolated from uninjured controls. Furthe

SUBMITTER: Agarwal S 

PROVIDER: S-EPMC4975503 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature