Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.

ABSTRACT: We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.

SUBMITTER: Thye T 

PROVIDER: S-EPMC4975513 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature