Circulating Progenitor Cells Identify Peripheral Arterial Disease in Patients With Coronary Artery Disease.

ABSTRACT:

Rationale

Peripheral arterial disease (PAD) is a clinical manifestation of extracoronary atherosclerosis. Despite sharing the same risk factors, only 20% to 30% of patients with coronary artery disease (CAD) develop PAD. Decline in the number of bone marrow-derived circulating progenitor cells (PCs) is thought to contribute to the pathogenesis of atherosclerosis. Whether specific changes in PCs differentiate patients with both PAD and CAD from those with CAD alone is unknown.

Objective

Determine whether differences exist in PCs counts of CAD patients with and without known PAD.

Methods and results

1497 patients (mean age: 65 years; 62% men) with known CAD were identified in the Emory Cardiovascular Biobank. Presence of PAD (n=308) was determined by history, review of

SUBMITTER: Hayek SS 

PROVIDER: S-EPMC4975640 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature