Are intracytoplasmic sperm injection and high serum estradiol compounding risk factors for adverse obstetric outcomes in assisted reproductive technology?

ABSTRACT:

Objective

To evaluate whether intracytoplasmic sperm injection (ICSI) use and E2 on the final day of assisted reproductive technology (ART) stimulation are associated with adverse obstetric complications related to placentation.

Design

Retrospective cohort study.

Setting

Large private ART practice.

Patient(s)

A total of 383 women who underwent ART resulting in a singleton live birth.

Intervention(s)

None.

Main outcome measure(s)

Adverse placental outcomes composed of placenta accreta, placental abruption, placenta previa, intrauterine growth restriction, preeclampsia, gestational hypertension, and small for gestational age infants.

Result(s)

Patients with adverse placental outcomes had higher peak serum E2 levels and were three times more l

SUBMITTER: Royster GD 

PROVIDER: S-EPMC4975645 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature