Antibodies against carbamylated proteins are present in primary Sjogren's syndrome and are associated with disease severity.

ABSTRACT:

Objectives

Herein, we investigate the presence and prognostic value of autoantibodies against carbamylated proteins (anti-CarP) in the serum of patients with primary Sjögren's syndrome (pSS).

Patients and methods

Serum levels of anti-CarP antibodies were measured in Norwegian patients with pSS (n=78) and corresponding controls (n=74) using ELISA and analysed in relation with exocrine gland function, degree of salivary gland inflammation, signs of ectopic germinal centre (GC) formation and immunological markers. For univariate comparisons, the Mann-Whitney U test and χ(2) or Fisher's exact tests were used. Correlations were assessed with Spearman's rank testing. Multivariate regression analyses were used to assess the effect of anti-CarP positivity on clinical manifestations.

SUBMITTER: Bergum B 

PROVIDER: S-EPMC4975850 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature