ERK and β-arrestin interaction: a converging point of signaling pathways for multiple types of cell surface receptors.

ABSTRACT: β-Arrestin, a signal adaptor protein, mediates intracellular signal transductions through protein-protein interactions by bringing two or more proteins in proximity. Extracellular signal-regulated kinase (ERK), a protein kinase in the family of mitogen-activated protein kinases (MAPKs), is involved in various receptor signal pathways. Interaction of ERK with β-arrestin or formation of ERK/β-arrestin signal complex occurs in response to activation of a variety of cell surface receptors. The ERK/β-arrestin signal complex may be a common transducer to converge a variety of extracellular stimuli to similar downstream intracellular signaling pathways. By using a cell-based protein-protein interaction LinkLight assay technology, we demonstrate a direct interaction between ERK and β-arrestin in r

SUBMITTER: Eishingdrelo H 

PROVIDER: S-EPMC4975872 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature