Association of diabetes and diabetes treatment with the host response in critically ill sepsis patients.

ABSTRACT:

Background

Diabetes is associated with chronic inflammation and activation of the vascular endothelium and the coagulation system, which in a more acute manner are also observed in sepsis. Insulin and metformin exert immune modulatory effects. In this study, we aimed to determine the association of diabetes and preadmission insulin and metformin use with sepsis outcome and host response.

Methods

We evaluated 1104 patients with sepsis, admitted to the intensive care unit and stratified according to the presence or absence of diabetes mellitus. The host response was examined by a targeted approach (by measuring 15 plasma biomarkers reflective of pathways implicated in sepsis pathogenesis) and an unbiased approach (by analyzing whole genome expression profiles in blood leukocyt

SUBMITTER: van Vught LA 

PROVIDER: S-EPMC4975896 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature