Small molecule ligands for bulged RNA secondary structures.

ABSTRACT: A class of wedge-shaped small molecules has been designed, synthesized, and shown to bind bulged RNA secondary structures. These minimally cationic ligands exhibit good affinity and selectivity for certain RNA bulges as demonstrated in a fluorescent intercalator displacement assay.

SUBMITTER: Meyer ST 

PROVIDER: S-EPMC4975938 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature