Localized aggressive periodontitis immune response to healthy and diseased subgingival plaque.

ABSTRACT:

Aim

The objective of this case-control study was to compare the inflammatory response of peripheral blood from localized aggressive periodontitis (LAP) patients when stimulated with healthy or diseased plaque samples.

Materials and methods

Whole blood and subgingival plaque samples were collected from 13 LAP subjects, 14 siblings of LAP subjects and six periodontally healthy individuals. Whole blood was stimulated for 24 h with plaque samples generated from healthy or diseased sites. The levels of 14 cyto/chemokines were detected using multiplex technology.

Results

Localized aggressive periodontitis-derived cultures displayed higher levels of G-CSF, INFγ, IL10, IL12p40, IL1β, IL-6, IL-8, MCP-1, MIP-1α, and TNFα, than control cultures regardless of stimulus used. Whole

SUBMITTER: Shaddox LM 

PROVIDER: S-EPMC4975966 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature