Ontology highlight
ABSTRACT:
SUBMITTER: Lee YJ
PROVIDER: S-EPMC4976040 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20160706 4
Invariant NKT cells differentiate into three predominant effector lineages in the steady state. To understand these lineages, we sorted undifferentiated invariant NK T progenitor cells and each effector population and analyzed their transcriptional profiles by RNAseq. Bioinformatic comparisons were made to effector subsets among other lymphocytes, specifically Th cells, innate lymphoid cells (ILC), and γδ T cells. Myc-associated signature genes were enriched in NKT progenitors, like in other hem ...[more]