Nanoscale studies link amyloid maturity with polyglutamine diseases onset.

ABSTRACT: The presence of expanded poly-glutamine (polyQ) repeats in proteins is directly linked to the pathogenesis of several neurodegenerative diseases, including Huntington's disease. However, the molecular and structural basis underlying the increased toxicity of aggregates formed by proteins containing expanded polyQ repeats remain poorly understood, in part due to the size and morphological heterogeneity of the aggregates they form in vitro. To address this knowledge gap and technical limitations, we investigated the structural, mechanical and morphological properties of fibrillar aggregates at the single molecule and nanometer scale using the first exon of the Huntingtin protein as a model system (Exon1). Our findings demonstrate a direct correlation of the morphological and mechanical prope

SUBMITTER: Ruggeri FS 

PROVIDER: S-EPMC4976327 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature