Real-Time Biological Annotation of Synthetic Compounds.

ABSTRACT: Organic chemists are able to synthesize molecules in greater number and chemical complexity than ever before. Yet, a majority of these compounds go untested in biological systems, and those that do are often tested long after the chemist can incorporate the results into synthetic planning. We propose the use of high-dimensional "multiplex" assays, which are capable of measuring thousands of cellular features in one experiment, to annotate rapidly and inexpensively the biological activities of newly synthesized compounds. This readily accessible and inexpensive "real-time" profiling method can be used in a prospective manner to facilitate, for example, the efficient construction of performance-diverse small-molecule libraries that are enriched in bioactives. Here, we demonstrate this concep

SUBMITTER: Gerry CJ 

PROVIDER: S-EPMC4976700 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature