Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease.

ABSTRACT: Brain imaging is essential for the diagnosis and characterization of cerebral small vessel disease. Several magnetic resonance imaging markers have therefore emerged, providing new information on the diagnosis, progression, and mechanisms of small vessel disease. Yet, the reproducibility of these small vessel disease markers has received little attention despite being widely used in cross-sectional and longitudinal studies. This review focuses on the main small vessel disease-related markers on magnetic resonance imaging including: white matter hyperintensities, lacunes, dilated perivascular spaces, microbleeds, and brain volume. The aim is to summarize, for each marker, what is currently known about: (1) its reproducibility in studies with a scan-rescan procedure either in single or multi

SUBMITTER: De Guio F 

PROVIDER: S-EPMC4976752 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature