Folate metabolic pathway single nucleotide polymorphisms: a predictive pharmacogenetic marker of methotrexate response in Indian (Asian) patients with rheumatoid arthritis.
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ABSTRACT: Aim
We evaluated the pharmacogenetic influence of genetic polymorphisms in folate pathway genes in Indian rheumatoid arthritis patients receiving methotrexate (MTX).Patients & methods
Twelve polymorphisms within nine folate pathway genes were analyzed for association with MTX response in 322 Indian rheumatoid arthritis (RA) patients and MTX pharmacokinetics in 94 RA patients.Results
Polymorphisms in GGH, SHMT1 and TS were associated with MTX-related adverse events while SNPs in MTHFR and RFC1/SLC19A1 were associated with MTX efficacy. TS5'UTR and SHMT1 polymorphisms were associated with higher plasma levels of MTX.Conclusion
Polymorphisms in folate-MTX pathway genes contribute to MTX response and affect MTX concentrations in Indian RA patients. A toxicogenetic index could identify patients who develop adverse events to MTX.
SUBMITTER: Ghodke-Puranik Y
PROVIDER: S-EPMC4976849 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Publications
Folate metabolic pathway single nucleotide polymorphisms: a predictive pharmacogenetic marker of methotrexate response in Indian (Asian) patients with rheumatoid arthritis.
Ghodke-Puranik Yogita Y Puranik Amrutesh S AS Shintre Pooja P Joshi Kalpana K Patwardhan Bhushan B Lamba Jatinder J Niewold Timothy B TB Chopra Arvind A
Pharmacogenomics 20151130 18
<h4>Aim</h4>We evaluated the pharmacogenetic influence of genetic polymorphisms in folate pathway genes in Indian rheumatoid arthritis patients receiving methotrexate (MTX).<h4>Patients & methods</h4>Twelve polymorphisms within nine folate pathway genes were analyzed for association with MTX response in 322 Indian rheumatoid arthritis (RA) patients and MTX pharmacokinetics in 94 RA patients.<h4>Results</h4>Polymorphisms in GGH, SHMT1 and TS were associated with MTX-related adverse events while S ...[more]
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Project description: Not available
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