Intracoronary Delivery of Mitochondria to the Ischemic Heart for Cardioprotection.

ABSTRACT: We have previously shown that transplantation of autologously derived, respiration-competent mitochondria by direct injection into the heart following transient ischemia and reperfusion enhances cell viability and contractile function. To increase the therapeutic potential of this approach, we investigated whether exogenous mitochondria can be effectively delivered through the coronary vasculature to protect the ischemic myocardium and studied the fate of these transplanted organelles in the heart. Langendorff-perfused rabbit hearts were subjected to 30 minutes of ischemia and then reperfused for 10 minutes. Mitochondria were labeled with 18F-rhodamine 6G and iron oxide nanoparticles. The labeled mitochondria were either directly injected into the ischemic region or delivered by vascular p

SUBMITTER: Cowan DB 

PROVIDER: S-EPMC4976938 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature