Microsphere-based gradient implants for osteochondral regeneration: a long-term study in sheep.

ABSTRACT:

Background

The microfracture technique for cartilage repair has limited ability to regenerate hyaline cartilage.

Aim

The current study made a direct comparison between microfracture and an osteochondral approach with microsphere-based gradient plugs.

Materials & methods

The PLGA-based scaffolds had opposing gradients of chondroitin sulfate and β-tricalcium phosphate. A 1-year repair study in sheep was conducted.

Results

The repair tissues in the microfracture were mostly fibrous and had scattered fissures with degenerative changes. Cartilage regenerated with the gradient plugs had equal or superior mechanical properties; had lacunated cells and stable matrix as in hyaline cartilage.

Conclusion

This first report of gradient scaffolds in a long-term, large

SUBMITTER: Mohan N 

PROVIDER: S-EPMC4977000 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature