Influence of Genetic Risk Factors on Coronary Heart Disease Occurrence in Afro-Caribbeans.

ABSTRACT:

Background

Despite excessive rates of cardiovascular risk factors such as hypertension, diabetes, and obesity, Afro-Caribbeans have lower mortality rates from coronary heart disease (CHD) than do whites. This study evaluated the association of genetic risk markers previously identified in whites and CHD in Afro-Caribbeans.

Methods

We studied 537 Afro-Caribbean individuals (178 CHD cases and 359 controls) who were genotyped for 19 CHD-related single-nucleotide polymorphisms (SNPs). A genetic risk score (GRS) incorporating the 19 SNPs was calculated. These participants were compared with 1360 white individuals from the Second Northwick Park Heart Study.

Results

In Afro-Caribbeans, patients with CHD had higher rates of hypertension (78.7% vs 30.1%), hypercholesterolemia

SUBMITTER: Larifla L 

PROVIDER: S-EPMC4977013 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature