Epigenome-Wide Assessment of DNA Methylation in the Placenta and Arsenic Exposure in the New Hampshire Birth Cohort Study (USA).

ABSTRACT:

Background

Arsenic is one of the most commonly encountered environmental toxicants, and research from model systems has suggested that one mode of its toxic activity may be through alterations in DNA methylation. In utero exposure to arsenic can affect fetal, newborn, and infant health, resulting in a range of phenotypic outcomes.

Objectives

This study examined variation in placental DNA methylation and its relationship to arsenic exposure in 343 individuals enrolled in the New Hampshire Birth Cohort Study.

Methods

Linear regression models using a reference-free correction to account for cellular composition were employed to determine CpG loci affected by arsenic levels.

Results

Total arsenic measured in maternal urine during the second trimester was not associ

SUBMITTER: Green BB 

PROVIDER: S-EPMC4977055 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature