Transplantation of spinal cord-derived neural stem cells for ALS: Analysis of phase 1 and 2 trials.

ABSTRACT:

Objective

To test the safety of spinal cord transplantation of human stem cells in patients with amyotrophic lateral sclerosis (ALS) with escalating doses and expansion of the trial to multiple clinical centers.

Methods

This open-label trial included 15 participants at 3 academic centers divided into 5 treatment groups receiving increasing doses of stem cells by increasing numbers of cells/injection and increasing numbers of injections. All participants received bilateral injections into the cervical spinal cord (C3-C5). The final group received injections into both the lumbar (L2-L4) and cervical cord through 2 separate surgical procedures. Participants were assessed for adverse events and progression of disease, as measured by the ALS Functional Rating Scale-Revised, force

SUBMITTER: Glass JD 

PROVIDER: S-EPMC4977116 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature