Mild traumatic brain injury-induced hippocampal gene expressions: The identification of target cellular processes for drug development.

ABSTRACT:

Background

Neurological dysfunction after traumatic brain injury (TBI) poses short-term or long-lasting health issues for family members and health care providers. Presently there are no approved medicines to treat TBI. Epidemiological evidence suggests that TBI may cause neurodegenerative disease later in life. In an effort to illuminate target cellular processes for drug development, we examined the effects of a mild TBI on hippocampal gene expression in mouse.

Methods

mTBI was induced in a closed head, weight drop-system in mice (ICR). Animals were anesthetized and subjected to mTBI (30g). Fourteen days after injury the ipsilateral hippocampus was utilized for cDNA gene array studies. mTBI animals were compared with sham-operated animals. Genes regulated by TBI were ident

SUBMITTER: Tweedie D 

PROVIDER: S-EPMC4977213 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature