Genetic characterization and phylogeny of pigeon paramyxovirus isolate (PPMV-1) from Pakistan.

ABSTRACT:

Background

Knowing the genome characteristics of circulating Newcastle disease viruses [avian paramyxoviruses (APMV-1) and pigeon paramyxoviruses (PPMV-1)] is important to devise appropriate diagnostics and control strategies. APMVs originating from chicken and wildlife in Pakistan are well-elucidated; nevertheless, molecular characterization for the circulating PPMV-1 is largely unknown.

Findings

Here, we have performed fusion (F) and hemagglutinin (HN) gene based characterization of PPMV-1 isolated from an outbreak in a pigeon flock. With F0 proteolytic cleavage site (112RRQKR↓F117), characteristic of velogenic/mesogenic serotype, the complete F and HN gene based sequence analysis of the isolate revealed evolutionary relationship to genotype VI. Further analysis of hyper-v

SUBMITTER: Akhtar S 

PROVIDER: S-EPMC4977264 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature