Gray matter maturation and cognition in children with different APOE ε genotypes.

ABSTRACT:

Objective

The aims of the current study were to determine whether children with the 6 different APOE ε genotypes show differences in gray matter maturation, particularly for those with ε4 and ε2 alleles, which are associated with poorer outcomes in many neurologic disorders.

Methods

A total of 1,187 healthy children (aged 3-20 years, 52.1% boys, 47.9% girls) with acceptable data from the cross-sectional Pediatric Imaging Neurocognition and Genetics Study were evaluated for the effects of 6 APOE ε genotypes on macroscopic and microscopic cortical and subcortical gray matter structures (measured with 3-tesla MRI and FreeSurfer for automated morphometry) and on cognition (NIH Toolbox).

Results

Among APOE ε4 carriers, age-related changes in brain structures and cognition

SUBMITTER: Chang L 

PROVIDER: S-EPMC4977368 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature