Impaired self-agency in functional movement disorders: A resting-state fMRI study.

ABSTRACT:

Objective

To investigate the neural mechanisms underlying impaired self-agency in patients with functional movement disorders using resting-state functional MRI (fMRI).

Methods

We obtained resting-state fMRI on 35 patients with clinically definite functional movement disorders and 35 age- and sex-matched healthy controls. Between-group differences in functional connectivity from the right temporo-parietal junction (TPJ), a region previously demonstrated to play a critical role in self-agency by comparing internal predictions of movement with actual external events, were assessed using t tests. All participants were screened for psychiatric diagnoses using a structured clinical interview and completed the Beck Depression Inventory and Childhood Trauma Questionnaire.

Result

SUBMITTER: Maurer CW 

PROVIDER: S-EPMC4977370 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature