Precise Tuning of Facile One-Pot Gelatin Methacryloyl (GelMA) Synthesis.

ABSTRACT: Gelatin-methacryloyl (GelMA) is one of the most commonly used photopolymerizable biomaterials in bio-applications. However, GelMA synthesis remains suboptimal, as its reaction parameters have not been fully investigated. The goal of this study is to establish an optimal route for effective and controllable GelMA synthesis by systematically examining reaction parameters including carbonate-bicarbonate (CB) buffer molarity, initial pH adjustment, MAA concentration, gelatin concentration, reaction temperature, and reaction time. We employed several analytical techniques in order to determine the degree of substitution (DS) and conducted detailed structural analysis of the synthesized polymer. The results enabled us to optimize GelMA synthesis, showing the optimal conditions to balance the dep

SUBMITTER: Shirahama H 

PROVIDER: S-EPMC4977492 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature