Role of plant MicroRNA in cross-species regulatory networks of humans.

ABSTRACT:

Background

It has been found that microRNAs (miRNAs) can function as a regulatory factor across species. For example, food-derived plant miRNAs may pass through the gastrointestinal (GI) tract, enter into the plasma and serum of mammals, and interact with endogenous RNAs to regulate their expression. Although this new type of regulatory mechanism is not well understood, it provides a fresh look at the relationship between food consumption and physiology. To investigate this new type of mechanism, we conducted a systematic computational study to analyze the potential functions of these dietary miRNAs in the human body.

Results

In this paper, we predicted human and plant target genes using RNAhybrid and set some criteria to further filter them. Then we built the cross-species

SUBMITTER: Zhang H 

PROVIDER: S-EPMC4977847 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature