Adjuvant pioglitazone for unremitted depression: Clinical correlates of treatment response.

ABSTRACT: Previous studies suggest that insulin-sensitizing agents could play a significant role in the treatment of major depression, particularly depression in patients with documented insulin resistance or those who are resistant to standard psychopharmacological approaches. This study aimed to assess the effects on depressive symptoms with adjuvant treatment with the PPARγ-agonist pioglitazone. Patients (N=37) with non-psychotic, non-remitting depression receiving standard psychiatric regimens for depression were randomized across an insulin sensitivity spectrum in a 12-week double blind, randomized controlled trial of pioglitazone or placebo. Improvement in depression was associated with improvement in glucose metabolism but only in patients with insulin resistance. An age effect was also shown

SUBMITTER: Lin KW 

PROVIDER: S-EPMC4978223 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature