Association Between Markers of Inflammation and Total Stroke by Hypertensive Status Among Women.

ABSTRACT:

Background

Markers of systemic inflammation (high-sensitivity C-reactive protein [hsCRP], soluble intercellular adhesion molecule 1 [sICAM-1], and fibrinogen) have been associated with a greater risk of total and ischemic stroke, in addition to elevated blood pressure. However, the role of these inflammatory markers on stroke pathophysiology by hypertension status is uncertain.

Methods

Blood samples were collected and assayed for hsCRP, sICAM-1, and fibrinogen among 27,330 initially healthy women from the Women's Health Study, and women were followed up from 1992 to 2013. Prior to randomization, the baseline questionnaire collected self-reported hypertension status, cardiovascular risk factors, and lifestyle factors. New cases of total, ischemic, and hemorrhagic stroke were

SUBMITTER: Jimenez MC 

PROVIDER: S-EPMC4978228 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature