Nonenzymatic biomimetic remodeling of phospholipids in synthetic liposomes.

ABSTRACT: Cell membranes have a vast repertoire of phospholipid species whose structures can be dynamically modified by enzymatic remodeling of acyl chains and polar head groups. Lipid remodeling plays important roles in membrane biology and dysregulation can lead to disease. Although there have been tremendous advances in creating artificial membranes to model the properties of native membranes, a major obstacle has been developing straightforward methods to mimic lipid membrane remodeling. Stable liposomes are typically kinetically trapped and are not prone to exchanging diacylphospholipids. Here, we show that reversible chemoselective reactions can be harnessed to achieve nonenzymatic spontaneous remodeling of phospholipids in synthetic membranes. Our approach relies on transthioesterification/ac

SUBMITTER: Brea RJ 

PROVIDER: S-EPMC4978229 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature