Genetic Variants in KLOTHO Associate With Cognitive Function in the Oldest Old Group.

ABSTRACT: Decline in cognitive abilities is a major concern in aging individuals. A potential important factor for functioning of the central nervous system in late-life stages is the KLOTHO (KL) gene. KL is expressed in various organs including the brain and is involved in multiple biological processes, for example, growth factor signaling. In the present study, 19 tagging gene variants in KL were studied in relation to 2 measures of cognitive function, a 5-item cognitive composite score and the Mini Mental State Examination, in 1,480 Danes 92-100 years of age. We found that heterozygotes for the previously reported KL-VS had poorer cognitive function than noncarriers. Two other variants positioned in the 5' end of the gene, rs398655 and rs562020, were associated with better cognitive function inde

SUBMITTER: Mengel-From J 

PROVIDER: S-EPMC4978356 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature