Association of Microvascular Function and Endothelial Biomarkers With Clinical Outcome in Dengue: An Observational Study.

ABSTRACT:

Background

The hallmark of severe dengue is increased microvascular permeability, but alterations in the microcirculation and their evolution over the course of dengue are unknown.

Methods

We conducted a prospective observational study to evaluate the sublingual microcirculation using side-stream dark-field imaging in patients presenting early (<72 hours after fever onset) and patients hospitalized with warning signs or severe dengue in Vietnam. Clinical findings, microvascular function, global hemodynamics assessed with echocardiography, and serological markers of endothelial activation were determined at 4 time points.

Results

A total of 165 patients were enrolled. No difference was found between the microcirculatory parameters comparing dengue with other febrile il

SUBMITTER: Yacoub S 

PROVIDER: S-EPMC4978369 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature