Persistent Sex Disparities in Invasive Pneumococcal Diseases in the Conjugate Vaccine Era.

ABSTRACT:

Background

Few studies have characterized the role of sex on the incidence of invasive pneumococcal disease (IPD). We examined sex differences in rates of IPD, and trends after the introduction of pneumococcal conjugate vaccines (PCVs).

Methods

We used active population and laboratory-based IPD surveillance data from the Centers for Disease Control and Prevention Active Bacterial Core surveillance program (1998-2013) in Tennessee. Population-based rates of IPD by sex, race, age group, and PCV era were calculated. Rates were compared using incidence rate ratios.

Results

Throughout the study years, rates of IPD were higher in male than in female subjects, particularly in children <2 years and adults 40-64 years of age, with male subjects having IPD rates 1.5-2 times hig

SUBMITTER: de St Maurice A 

PROVIDER: S-EPMC4978370 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature