Relevance of New Definitions to Incidence and Prognosis of Acute Kidney Injury in Hospitalized Patients with Cirrhosis: A Retrospective Population-Based Cohort Study.

ABSTRACT:

Background

The implementation of new serum creatinine (SCr)-based criteria for acute kidney injury (AKI) has brought to light several areas of uncertainty in patients with cirrhosis.

Study design

Population-based cohort study.

Setting & participants

Adults with cirrhosis hospitalized between 2002-2012.

Predictor

We aimed to address the prognostic implications of the new AKI criteria in cirrhosis.

Outcomes

Baseline kidney function was defined from all outpatient SCr within 3 months before hospitalization. Cox proportional hazards models were fit to examine associations between AKI, renal recovery and all-cause mortality.

Results

4,733 patients were studied. The 30-day mortality was higher for participants with AKI (43.9% vs 8.5%; p-value<0.001), an

SUBMITTER: Tandon P 

PROVIDER: S-EPMC4978466 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature