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A spinal analog of memory reconsolidation enables reversal of hyperalgesia.

ABSTRACT: Hyperalgesia arising from sensitization of pain relays in the spinal dorsal horn shares many mechanistic and phenotypic parallels with memory formation. We discovered that mechanical hyperalgesia could be rendered labile and reversible in mice after reactivation of spinal pain pathways in a process analogous to memory reconsolidation. These findings reveal a previously unknown regulatory mechanism underlying hyperalgesia and demonstrate the existence of reconsolidation-like processes in a sensory system.

SUBMITTER: Bonin RP

PROVIDER: S-EPMC4978538 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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A spinal analog of memory reconsolidation enables reversal of hyperalgesia.

Bonin Robert P RP De Koninck Yves Y

Nature neuroscience 20140706 8

Hyperalgesia arising from sensitization of pain relays in the spinal dorsal horn shares many mechanistic and phenotypic parallels with memory formation. We discovered that mechanical hyperalgesia could be rendered labile and reversible in mice after reactivation of spinal pain pathways in a process analogous to memory reconsolidation. These findings reveal a previously unknown regulatory mechanism underlying hyperalgesia and demonstrate the existence of reconsolidation-like processes in a sensor ...[more]

PMID: 24997764

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