Impaired Exercise Performance and Skeletal Muscle Mitochondrial Function in Rats with Secondary Carnitine Deficiency.

ABSTRACT:

Purpose

The effects of carnitine depletion upon exercise performance and skeletal muscle mitochondrial function remain largely unexplored. We therefore investigated the effect of N-trimethyl-hydrazine-3-propionate (THP), a carnitine analog inhibiting carnitine biosynthesis and renal carnitine reabsorption, on physical performance and skeletal muscle mitochondrial function in rats.

Methods

Male Sprague Dawley rats were treated daily with water (control rats; n = 12) or with 20 mg/100 g body weight THP (n = 12) via oral gavage for 3 weeks. Following treatment, half of the animals of each group performed an exercise test until exhaustion.

Results

Distance covered and exercise performance were lower in THP-treated compared to control rats. In the oxidative soleus muscle,

SUBMITTER: Bouitbir J 

PROVIDER: S-EPMC4978712 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature