GEVAL - a web-based browser for evaluating genome assemblies.

ABSTRACT:

Motivation

For most research approaches, genome analyses are dependent on the existence of a high quality genome reference assembly. However, the local accuracy of an assembly remains difficult to assess and improve. The gEVAL browser allows the user to interrogate an assembly in any region of the genome by comparing it to different datasets and evaluating the concordance. These analyses include: a wide variety of sequence alignments, comparative analyses of multiple genome assemblies, and consistency with optical and other physical maps. gEVAL highlights allelic variations, regions of low complexity, abnormal coverage, and potential sequence and assembly errors, and offers strategies for improvement. Although gEVAL focuses primarily on sequence integrity, it can also display arbit

SUBMITTER: Chow W 

PROVIDER: S-EPMC4978925 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature