MINTbase: a framework for the interactive exploration of mitochondrial and nuclear tRNA fragments.

ABSTRACT:

Motivation

It has been known that mature transfer RNAs (tRNAs) that are encoded in the nuclear genome give rise to short molecules, collectively known as tRNA fragments or tRFs. Recently, we reported that, in healthy individuals and in patients, tRFs are constitutive, arise from mitochondrial as well as from nuclear tRNAs, and have composition and abundances that depend on a person's sex, population origin and race as well as on tissue, disease and disease subtype. Our findings as well as similar work by other groups highlight the importance of tRFs and presage an increase in the community's interest in elucidating the roles of tRFs in health and disease.

Results

We created MINTbase, a web-based framework that serves the dual-purpose of being a content repository for tRFs an

SUBMITTER: Pliatsika V 

PROVIDER: S-EPMC4978933 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature