Transcriptomic evidence for modulation of host inflammatory responses during febrile Plasmodium falciparum malaria.

ABSTRACT: Identifying molecular predictors and mechanisms of malaria disease is important for understanding how Plasmodium falciparum malaria is controlled. Transcriptomic studies in humans have so far been limited to retrospective analysis of blood samples from clinical cases. In this prospective, proof-of-principle study, we compared whole-blood RNA-seq profiles at pre-and post-infection time points from Malian adults who were either asymptomatic (n = 5) or febrile (n = 3) during their first seasonal PCR-positive P. falciparum infection with those from malaria-naïve Dutch adults after a single controlled human malaria infection (n = 5). Our data show a graded activation of pathways downstream of pro-inflammatory cytokines, with the highest activation in malaria-naïve Dutch individuals and signific

SUBMITTER: Tran TM 

PROVIDER: S-EPMC4978957 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature