Genome-Wide Association of the Laboratory-Based Nicotine Metabolite Ratio in Three Ancestries.

ABSTRACT:

Introduction

Metabolic enzyme variation and other patient and environmental characteristics influence smoking behaviors, treatment success, and risk of related disease. Population-specific variation in metabolic genes contributes to challenges in developing and optimizing pharmacogenetic interventions. We applied a custom genome-wide genotyping array for addiction research (Smokescreen), to three laboratory-based studies of nicotine metabolism with oral or venous administration of labeled nicotine and cotinine, to model nicotine metabolism in multiple populations. The trans-3'-hydroxycotinine/cotinine ratio, the nicotine metabolite ratio (NMR), was the nicotine metabolism measure analyzed.

Methods

Three hundred twelve individuals of self-identified European, African, and Asi

SUBMITTER: Baurley JW 

PROVIDER: S-EPMC4978985 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature