Ontology highlight
ABSTRACT:
SUBMITTER: Tian GA
PROVIDER: S-EPMC4978997 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Scientific reports 20160810
Gastrointestinal stromal tumor (GIST) is the most major mesenchymal neoplasm of the digestive tract. Up to now, imatinib mesylate has been used as a standard first-line treatment for irresectable and metastasized GIST patients or adjuvant treatment for advanced GIST patients who received surgical resection. However, secondary resistance to imatinib usually happens, resulting in a major obstacle in GIST successful therapy. In this study, we first found that collagen and calcium binding EGF domain ...[more]