"Grafting to" of RAFTed Responsive Polymers to Glass Substrates by Thiol-Ene and Critical Comparison to Thiol-Gold Coupling.

ABSTRACT: Surface-grafted polymers have been widely applied to modulate biological interfaces and introduce additional functionality. Polymers derived from reversible addition-fragmentation transfer (RAFT) polymerization have a masked thiol at the ω-chain end providing an anchor point for conjugation and in particular displays high affinity for gold surfaces (both flat and particulate). In this work, we report the direct grafting of RAFTed polymers by a "thiol-ene click" (Michael addition) onto glass substrates rather than gold, which provides a more versatile surface for subsequent array-based applications but retains the simplicity. The immobilization of two thermoresponsive polymers are studied here, poly[oligo(ethylene glycol) methyl ether methacrylate] (pOEGMA) and poly(N-isopropylacrylamide) (

SUBMITTER: Biggs CI 

PROVIDER: S-EPMC4979048 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature