Differential expression of skeletal muscle genes following administration of clenbuterol to exercised horses.

ABSTRACT:

Background

Clenbuterol, a beta2-adrenergic receptor agonist, is used therapeutically to treat respiratory conditions in the horse. However, by virtue of its mechanism of action it has been suggested that clenbuterol may also have repartitioning affects in horses and as such the potential to affect performance. Clenbuterol decreases the percent fat and increases fat-free mass following high dose administration in combination with intense exercise in horses. In the current study, microarray analysis and real-time PCR were used to study the temporal effects of low and high dose chronic clenbuterol administration on differential gene expression of several skeletal muscle myosin heavy chains, genes involved in lipid metabolism and the β2-adrenergic receptor. The effect of clenbuterol ad

SUBMITTER: Knych HK 

PROVIDER: S-EPMC4979108 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature