A Quick-responsive DNA Nanotechnology Device for Bio-molecular Homeostasis Regulation.

ABSTRACT: Physiological processes such as metabolism, cell apoptosis and immune responses, must be strictly regulated to maintain their homeostasis and achieve their normal physiological functions. The speed with which bio-molecular homeostatic regulation occurs directly determines the ability of an organism to adapt to conditional changes. To produce a quick-responsive regulatory system that can be easily utilized for various types of homeostasis, a device called nano-fingers that facilitates the regulation of physiological processes was constructed using DNA origami nanotechnology. This nano-fingers device functioned in linked open and closed phases using two types of DNA tweezers, which were covalently coupled with aptamers that captured specific molecules when the tweezer arms were sufficiently

SUBMITTER: Wu S 

PROVIDER: S-EPMC4979213 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature