Efficacy of skin-directed therapy for cutaneous metastases from advanced cancer: a meta-analysis.

ABSTRACT:

Purpose

To perform the first meta-analysis of the efficacy of skin-directed therapies for cutaneous metastases.

Methods

MEDLINE, EMBASE, The Cochrane Library, and ClinicalTrials.gov databases were searched for reports of prospective clinical studies published between 1960 and 2013 that assessed the response of skin-directed therapy for cutaneous metastases (47 of 2,955 unique studies were selected). Primary end points of the study were complete and objective response rates. Secondary analyses were preplanned and included subgroup analyses by skin-directed therapy, histology, and recurrence rates. Meta-analyses were performed with random-effect modeling, and extent of heterogeneity between studies was determined with the Cochran Q and I(2) tests.

Results

After applying

SUBMITTER: Spratt DE 

PROVIDER: S-EPMC4979225 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature