Altered Development of Amygdala-Anterior Cingulate Cortex Connectivity in Anxious Youth and Young Adults.

ABSTRACT:

Background

Development of cortico-amygdala circuitry underlies the maturation of emotion processing and regulation, and age-related changes in amygdala connectivity with anterior cingulate cortex (ACC) have been shown to mediate normative developmental decreases in anxiety. It remains unclear whether developmental changes in this circuitry relate to pathological anxiety in youth. The current functional magnetic resonance imaging (fMRI) study addresses this question by examining amygdala functional connectivity in anxious and healthy individuals spanning the developmental period from childhood through adulthood.

Methods

Youth and young adults (age 7-25) with current anxiety disorders (n=57) and healthy comparisons (n=61) completed an fMRI emotional face processi

SUBMITTER: Kujawa A 

PROVIDER: S-EPMC4979579 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature